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Antibody Engineering03 / 10
Specialist serviceFc Engineering for Function, Stability, and Clinical Success
Enhance effector function, extend half-life or silence activity with Fc region modifications designed by our expert team.
30+ years of antibody expertise250+ humanization projectsOne integrated scientific team
Published from Fusion CMS
Fc Engineering for Function, Stability, and Clinical Success
Enhance effector function, extend half-life or silence activity with Fc region modifications designed by our expert team.
Why FC Engineering Matters
The Fc (Fragment crystallizable) region governs critical antibody properties, influencing immune system engagement, recycling via FcRn, and product stability. Tailoring this region enables developers to fine-tune the antibody's function to align with their therapeutic goal.
Whether your program requires enhanced ADCC, silencing of immune activity, or extended serum persistence, our team delivers precision-engineered Fc variants designed to meet regulatory and clinical expectations.
Custom Modifications to Suit your Application
| Engineering Goal | Purpose |
|---|---|
| Effector Function Enhancement | |
| Effector Silencing | To reduce or eliminate interaction with Fcγ receptors and complement proteins, minimizing immune activation |
| Half-Life Extension | To prolong the antibody's circulation time by increasing its interaction with the neonatal Fc |
| Fc-Fusion Constructs | |
| Manufacturability optimization | To improve expression, stability, solubility, and reduce aggregation or degradation during production and storage |
Our Fc Engineering Approach
Goal Definition We work with you to define the optimal Fc profile based on therapeutic indication and mechanism of action..
Design & In Silico Evaluation Selection of optimal Fc mutations based on structural knowledge and literature-supported variants.
Expression & Screening Fc variants produced in mammalian cells and screened for activity, stability, and yield.
Biophysical & Functional Characterisation Comprehensive evaluation including including ADCC, CDC, FcRn binding, and thermal stability.
Developability Risk Assessment Early identification of potential a of aggregation, clearance, and manufacturability issues to streamline downstream development.
With decades of antibody engineering expertise, Fusion Antibodies combines deep Fc biology knowledge with proven developability insight. Our integrated approach ensures Fc modifications are not only functionally optimized, but also manufacturable, scalable, and aligned with your expectations.
By partnering with Fusion Antibodies, you gain a trusted team that de-risks development, accelerates timelines, and delivers Fc-engineered antibodies built for success.
A connected workflow
Start with the biology, share the context and move forward with confidence.
Questions, answered
Can this capability connect to another Fusion service? ＋
Yes. Our teams are designed to share context across discovery, engineering and supply.
Tell us what you’re working on.
Share the useful starting details and your enquiry will be sent securely to Fusion’s scientific team.
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